EFFICACY & SAFETY

QUALITY OF LIFE

Frequent nasal allergies demand better management and control1

Ongoing exposure to increased allergens in the environment is a key factor to a rise in chronic allergic rhinitis, an increase in the severity of nasal allergy symptoms, and corresponding deterioration in patients’ quality of life.2,3

Surveys show that:

Suffering from allergic rhinitis may go beyond symptoms

Your patient may also be experiencing these physical and emotional impacts:4,5

Tiredness

85%

Irritability

67%

Feeling Miserable

60%

Sleep Disturbances

57%

Feelings of Depression

28%

Embarrassment

15%

  • 0
  • 20
  • 40
  • 60
  • 80
  • 100

Flonase® Allergy Relief can help reduce symptoms of allergic rhinitis that affect quality of life

  • Patients also reported an improved sense of well-being and a superior impact on attendance and performance at work, school, home, and in daily leisure/recreational activities as compared with patients treated with placebo and an antihistamine.6
  • Effective symptom control with Flonase® Allergy Relief can also help relieve the tiredness and irritability associated with nasal allergies.7,8

Efficacy

Indicated for the relief of itchy, watery eyes, without a prescription||9

  • Significant relief of ocular itching and tearing due to nasal allergies10
  • Clinicians reported that Flonase® provided a >40% improvement of total ocular symptom scores (TOSS) in 7 days vs. 26% with placebo and a 50% improvement of TOSS in 14 days vs. 31% with placebo.10

Treats nasal allergy symptoms

When taken regularly, Flonase® Allergy Relief can help treat nasal allergy symptoms and manage sinus pain and pressure.11,12

Proven effective for seasonal and perennial allergic symptoms

  • In a study of seasonal allergic rhinitis (SAR) symptom relief, patients who took Flonase® experienced >2x the reduction of symptom scores at day 4, and sustained this outcome through the duration of the study13
  • In 59% of patients with perennial allergic rhinitis (PAR), Flonase® significantly lowered total nasal symptoms scores (TNSS)—measuring the sum of obstruction, rhinorrhea, sneezing, and itching—at week one and throughout treatment§14

Because of the way it works, it may take several days for Flonase® Allergy Relief to reach maximum effect. Patients should be advised to take Flonase® Allergy Relief regularly, once a day.9

RELIEF FROM:9

Helps relief nasal congestion

NASAL CONGESTION

Runny nose

RUNNY NOSE

Helps relieve sneezing

SNEEZING

Helps relieve sinus pain and pressure

SINUS PAIN AND PRESSURE

Helps relieve itchy, watery eyes

ITCHY, WATERY EYES

Helps relieve itchy nose and throat

ITCHY NOSE AND THROAT

BTC in Quebec, Schedule II.Based on recalculation of published data.Flonase® Allergy Relief 200 µg QD vs. placebo.Flonase® Allergy Relief 200 µg QD at end of treatment.Adults 18 years of age and older who need to use daily for longer than 3 months, should consult a doctor.

ONSET

  • In some patients, Flonase® Allergy Relief starts to act on allergy symptoms in the first day.9
  • Maximum benefit could take 2-3 days after the start of therapy.9

For maximum benefit, advise patients with allergies to continue taking Flonase® Allergy Relief for 1 week, then make it part of their daily routine.§6,9 Ensure patients are taking Flonase® Allergy Relief properly.

If symptoms are under control after 1 week of use, the dose should be lowered to 1 spray in each nostril once a day. Adults 18 years of age and older who need to use daily for longer than 3 months, should consult a doctor.

Some patients may feel relief within 12-24 hours of use. Maximum effect could take 2–3 days

Some patients may feel relief as soon as the first day.9

Maximum effect could take 2–3 days after the start of therapy.9

SAFETY

A well-established safety profile6

Low Systemic Absorption

Flonase® Allergy Relief is a corticosteroid with low (<1%) systemic absorption.6 Low-systemic absorption minimizes the potential for systemic side effects that are a concern with other corticosteroids used to treat allergic rhinitis, such as prednisone.15,16

Approved to treat year-round symptoms6

  • INS treatments are recognized as the most effective long-term treatment options for allergic rhinitis16
  • Adults 18 years of age and older who need to use daily for longer than 3 months, should consult a doctor9

Flonase® Allergy Relief:

Is NOT associated with higher blood pressure and is not contraindicated in patients with:9

  • Hypertension
  • Heart disease
  • Diabetes
  • Liver disease
  • Kidney disease

Is NOT associated with common side effects associated with some other allergy medications.

  • Does not cause:6,17-20
  • Drowsiness
  • Dry mouth
  • Nervousness
  • Dizziness
  • Sleeplessness

Fluticasone propionate, the active ingredient in Flonase® Allergy Relief, has been trusted by doctors and pharmacists to relieve allergy symptoms for over 20 years.6,9

REFERENCES

  1. Beggs PJ. Impacts of climate change on aeroallergens: past and future. Clin Exp Allergy. 2004;34(10):1507-1513.
  2. D’Amato G. Urban air pollution and plant-derived respiratory allergy. Clin Exp Allergy. 2000;30(5):628-636.
  3. Géhanno P, Desfougeres JL. Fluticasone propionate aqueous nasal spray compared with oral loratadine in patients with seasonal allergic rhinitis. Allergy. 1997;52(4):445-450.
  4. Brooks M. Allergic rhinitis a significant burden. http://www.medscape.com/viewarticle/739928. Published March 30, 2011. Accessed March 27, 2014.
  5. World Allergy Organization. World Allergy Organization (WAO) White Book on Allergy. Milwaukee, WI: World Allergy Organization; 2011.
  6. Data on file. GlaxoSmithKline. 2016.
  7. Craig TJ, Teets S, Lehman EB, Chinchilli VM, Zwillich C. Nasal congestion secondary to allergic rhinitis as a cause of sleep disturbance and daytime fatigue and the response to topical nasal corticosteroids. J Allergy Clin Immunol. 1998;101(5):633-637.
  8. Sardana N, Craig TJ. Congestion and sleep impairment in allergic rhinitis. Asian Pac J Allergy Immunol. 2011;29(4):297-306.
  9. Flonase® Allergy Relief Product Monograph. GlaxoSmithKline Consumer Healthcare Inc. August 23, 2016.
  10. DeWester J, Philpot EE, Westlund RE, Cook CK, Rickard KA. The efficacy of intranasal fluticasone propionate in the relief of ocular symptoms associated with seasonal allergic rhinitis. Allergy Asthma Proc. 2003;24(5):331-337.
  11. Darnell R, Pecoud A, Richards DH. A double-blind comparison of fluticasone propionate aqueous nasal spray, terfenadine tablets and placebo in the treatment of patients with seasonal allergic rhinitis to grass pollen. Clin Exp Allergy. 1994;24(12):1144-1150.
  12. Benincasa C, Lloyd RS. Evaluation of fluticasone propionate aqueous nasal spray taken alone and in combination with cetirizine in the prophylactic treatment of seasonal allergic rhinitis. Drug Invest. 1994;8(4):225-233.
  13. Nathan RA, Bronsky EA, Fireman P, et al. Once daily fluticasone propionate aqueous nasal spray is an effective treatment for seasonal allergic rhinitis. Ann Allergy. 1991;67(3):332-338.
  14. Banov CH, Woehler TR, LaForce CF, et al. Once daily intranasal fluticasone propionate is effective for perennial allergic rhinitis. Ann Allergy. 1994;73(3)240-246.
  15. MedlinePlus. Prednisone. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a601102.html. Accessed April 1, 2014.
  16. Greiner AN, Meltzer EO. Overview of the treatment of allergic rhinitis and nonallergic rhinopathy. Proc Am Thorac Soc. 2011;8(1):121-131.
  17. MedlinePlus. Clemastine. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682542.html. Accessed April 1, 2014.
  18. MedlinePlus. Diphenhydramine. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682539.html. Accessed April 1, 2014.
  19. MedlinePlus. Chlorpheniramine. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682543.html. Accessed April 1, 2014.
  20. MedlinePlus. Pseudoephedrine. http://www.nlm.nih.gov/medlinepous/druginfo/meds/a682619.html. Accessed April 1, 2014.
FRANÇAIS