Global environmental changes are causing allergic rhinitis to increase in incidence and prevalence.1

Smoke stack to indicate climate change
Thunder storm to indicate spring
Tree to indicate pollen

Climate changes increase CO2 levels worldwide, which in turn affect plants1

  • Earlier bloom times, where spring pollen season begins 6 days earlier than it did in the 1960s2
  • Longer growing season, which lengthens pollen season (some reports state an increased duration of 13-27 days)3
  • Bigger, stronger plants that generate increased pollen production (estimated future increases of 90% are predicted)1

Flonase® Allergy Relief can help treat and manage today's allergic rhinitis symptoms

Flonase® Allergy Relief can be used by adults 18 years of age and older once daily for up to 3 months as part of a regular nasal allergy treatment regimen.4,5 When taken regularly before exposure to allergens, Flonase® Allergy Relief can prevent nasal allergy symptoms from developing.6,7 Relief starts with the first dose for some patients.4,5

For patients 18 years of age or older: if use of Flonase® Allergy Relief is needed beyond 3 months, patients should consult their doctor.5


Help your patients know the facts and dispel the myths about nasal allergy treatment so they can get the symptom relief they need.


Mechanism vs. most OTC allergy pills. Flonase® Allergy Relief acts on multiple key inflammatory substances (including histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.After 3 months of daily use, the patient should consult their doctor if they can continue using Flonase® Allergy Relief.


  1. Beggs PJ. Impacts of climate change on aeroallergens: past and future. Clin Exp Allergy. 2004;34(10):1507-1513.
  2. Menzel A, Fabian P. Growing season extended in Europe. Nature. 1999;37:659.
  3. Ziska L, Knowlton K, Rogers C, et al. Recent warming by latitude associated with increased length of ragweed pollen season in central North America. Proc Natl Acad Sci USA. 2011;108(10):4248-4251.
  4. Data on file. GlaxoSmithKline. 2016.
  5. Flonase® Allergy Relief Product Monograph. GlaxoSmithKline Consumer Healthcare Inc. August 23, 2016.
  6. Darnell R, Pecoud A, Richards DH. A double-blind comparison of fluticasone propionate aqueous nasal spray, terfenadine tablets and placebo in the treatment of patients with seasonal allergic rhinitis to grass pollen. Clin Exp Allergy. 1994;24(12):1144-1150.
  7. Benincasa C, Lloyd RS. Evaluation of fluticasone propionate aqueous nasal spray taken alone and in combination with cetirizine in the prophylactic treatment of seasonal allergic rhinitis. Drug Invest. 1994;8(4):225-233.
  8. WebMD. Nasal spray: are you overdoing it? Accessed October 16, 2014.
  9. Derendorf H, Meltzer EO. Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy. 2008;63(10):1292-1300.
  10. Brooks M. Allergic rhinitis a significant burden. Medscape website. Published March 30, 2011. Accessed March 27, 2014.
  11. Craig TJ, Teets S, Lehman EB, Chinchilli VM, Zwillich C. Nasal congestion secondary to allergic rhinitis as a cause of sleep disturbance and daytime fatigue and the response to topical nasal corticosteroids. J Allergy Clin Immunol. 1998;101(5):633-637.
  12. Sardana N, Craig TJ. Congestion and sleep impairment in allergic rhinitis. Asian Pac J Allergy Immunol. 2011;29(4):297-306.
  13. World Allergy Organization. Pawankar R, Canonica GW, Holgate ST, Lockey RF, eds. World Allergy Organization (WAO) White Book on Allergy. Milwaukee, WI: World Allergy Organization; 2011.
  14. Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA). Allergy. 2008;63(suppl 86):8-160.
  15. Ratner PH, van Bavel JH, Martin BG, et al. A comparison of the efficacy of fluticasone propionate aqueous nasal spray and loratadine, alone and in combination, for the treatment of seasonal allergic rhinitis. J Fam Pract. 1998;47(2):118-125.
  16. Bachert C, Geveart P. Effect of intranasal corticosteroids on release of cytokines and inflammatory mediators. Allergy. 1999;54(suppl 57):116-123.
  17. MedlinePlus. Prednisone. Accessed April 1, 2014.
  18. Yawn BP. Comparison of once-daily intranasal corticosteroids for the treatment of allergic rhinitis: are they all the same? Med Gen Med. 2006;8(1):23.